The majority (70.3%) of false positive smears had ≥2+ smear results with the MetaSystems platform. The sensitivity of the MetaSystems platform was not impacted by smear grade or mycobacterial species. When positive scans were used to assist technologists, the MetaSystems platform had a sensitivity of 70.7% (94/133 95% CI 62.2 to 78.3) and specificity of 89.0% (323/363 95% CI 85.3 to 92.0). The MetaSystems platform failed to scan 57 (11.5%) slides. Culture results were used as the reference method.
The sensitivity and specificity of the MetaSystems platform was measured as a standalone diagnostic and as an assistant to technologists to review positive images. Auramine O-stained slides corresponding to 133 culture-positive and 363 culture-negative respiratory ( n = 284), tissue ( n = 120), body fluid ( n = 81), and other ( n = 11) sources were evaluated with the MetaSystems Mycobacteria Scanner running the NEON Metafer AFB Module. The aim of this study was to evaluate the accuracy of MetaSystems’ automated fluorescent AFB slide scanner and analyzer.
Manual reading of fluorescent acid-fast bacilli (AFB) microscopy slides is time-intensive and technically demanding.
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